About Mean Corpuscular Hemoglobin Concentration
MCHC (Mean Corpuscular Haemoglobin Concentration) measures the concentration of haemoglobin within the average red blood cell — how densely packed the haemoglobin is. Low MCHC reflects hypochromic (pale, iron-deficient) red cells; high MCHC is less common but is characteristically seen in hereditary spherocytosis, a genetic red cell membrane disorder. MCHC is also a quality-control marker for laboratory analysers, since it has a very narrow physiological range and can flag haemolysed samples or lab errors.