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Thyroglobulin is a protein produced by thyroid follicular cells, serving as the precursor for thyroid hormones T3 and T4. After thyroid cancer surgery, thyroglobulin functions as a tumor marker — rising levels signal possible cancer recurrence. Thyroglobulin must always be interpreted alongside thyroglobulin antibodies, which can interfere with measurement.
Also known as: Tg, Thyroglobulin, Thyroglobuline, Tiroglobulina, 갑상선글로불린, 甲状腺球蛋白
High thyroglobulin in a post-thyroidectomy patient strongly suggests thyroid cancer recurrence. In intact thyroid patients, elevated thyroglobulin indicates thyroid inflammation, goiter, or hyperthyroidism.
Standard range for intact thyroid is 1.5-38 ng/mL. After thyroid cancer surgery, the target is undetectable. Thyroglobulin must be interpreted alongside TgAb, which can interfere with measurement.