About Globulin
Globulin is the collective term for a diverse group of blood proteins produced by the liver and the immune system — including clotting factors, carrier proteins, complement proteins, and immunoglobulins (antibodies). Elevated globulin (hyperglobulinaemia) is a red flag for chronic inflammation, autoimmune disease, chronic liver disease, or a monoclonal antibody-producing condition like multiple myeloma. Low globulin suggests immune deficiency or severe protein malnutrition. The albumin-to-globulin ratio below 1.0 is particularly useful in flagging plasma cell disorders.