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IGF-1 (Insulin-like Growth Factor 1) is produced primarily by the liver in response to growth hormone and serves as the stable mediator of GH's anabolic effects on muscle, bone, and tissue repair. In the longevity field, moderate IGF-1 levels may balance tissue maintenance against cancer risk. IGF-1 is the preferred clinical test for diagnosing GH deficiency or excess.
Also known as: IGF-1, IGF-I, IGF1, Insulin-Like Growth Factor 1, Somatomedin C, 胰岛素样生长因子-I
High IGF-1 is seen in acromegaly and associated with increased cancer risk. Low IGF-1 indicates GH deficiency, malnutrition, or liver disease.
Standard ranges are age-dependent. Longevity practitioners target moderate IGF-1 (120-180 ng/mL) to balance tissue maintenance against cancer risk.